Screening for Mutations of MODY 1-5 Genes in Chinese Families with Early-onset Type 2 Diabetes
- VernacularTitle:中国早发2型糖尿病家系MODY 1-5基因测定
- Author:
Jinhua YAN
;
Yunfeng SHEN
;
Qiuqiong YU
;
Hua LIANG
;
Mengyin CAI
;
Jianping WENG
- Publication Type:Journal Article
- Keywords:
early-onset type 2 diabetes;
gene mutation;
maturity-onset diabetes of the young
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2009;30(4):437-440,封3
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] The aim of our study was to seek the mutations in MODY1～5 genes in Chinese population by direct sequencing in probands from families with early-onset type 2 diabetes.[Methods] Variants screening in MODY 1-5 genes were performed by PCR and direct sequencing in 19 probands from early-onset type 2 diabetes families.[Results] We found no mutation but many polymorphisms.There were 6,5,15,1,and 1 variants in MODY 1-5 genes respectively.[Conclusion] Our negative results in MODY genes suggest the genetic heterogeneity of different populations.Mutations in MODY 1-5 genes might not be the cause of diabetes in those 19 families.
