Effect of nitric oxide and inducible nitric oxide synthase in experimental aortic aneurysm
- VernacularTitle:一氧化氮、诱导性一氧化氮合酶在实验性大鼠腹主动脉瘤中的作用
- Author:
Yong LIU
;
Yanzheng HE
;
Mei LIN
;
Xicheng ZHANG
;
Hong ZENG
- Publication Type:Journal Article
- Keywords:
Aortic aneurysm,abdominal?Nitric-oxide synthase?Nitric oxide?Gelatinase B
- From:Chinese Journal of Current Advances in General Surgery
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of nitric oxide(NO) and inducible nitric oxide synthase (iNOS) in the experimental abdominal aortic aneurysm (AAA) rat model.Methods:An intra-aortic elastase infusion model was used.Control rats received intra-aortic saline infusion.In the remaining groups,intra-aortic elastase infusion was used to induce aneurysm formation.These rats were treated with intraperitoneal injections of saline postoperatively(experimental group),aminoguanidine postoperatively(medicine group).Serum NO and aortic diameter were measured,Changes of histology,iNOS and MMP-9 were observed in the aortic wall.Results:Experimental group produced AAAs with significant production of iNOS,MMPs and serum NO compared with controls.In medicine group reduced aneurysm size and displayed suppression of MMPs expression,inflammatory infiltrates and serum NO production were detected.Conclusion:Expression of iNOS and MMP-9 are induced and serum NO levels are increased in experimental AAA,iNOS and NO production by iNOS play an important role with detrimental effects during experimental aneurysm development.
