Effect of low-selenium diet on apoptosis of cardiac myocytes in rats and melatonin's protective effects
- VernacularTitle:硒缺乏对大鼠心肌细胞凋亡的影响及褪黑素的干预作用
- Author:
Chaoying ZHANG
;
Yinhu DANG
;
Hui WANG
;
Baoshan SU
- Publication Type:Journal Article
- Keywords:
selenium;
apoptosis;
melatonin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship betwe en low-selenium diet and apoptosis of cardiac myocytes in rats and if melatonin c an have protective effects on the damage. Methods The level of myocardial MDA in rats' was measured a nd apoptosis of cardiac myocytes in rats was detected in the three groups of rat s, fed with low-selenium diet, sufficient-selenium diet and low-selenium diet plus intragastric administration of melatonin, respectively. Results The level of MDA in myocardium was significantly hi gher in low-selenium group than that in sufficient-selenium group and low-sel enium group with intragastric administration of melatonin (P
