The effects of endothelin-1 and stem cell factor on melanocyte adhesion and migration in vitro
- VernacularTitle:内皮素-1和干细胞因子对黑素细胞黏附和迁移影响的对照研究
- Author:
Zhiling ZHANG
;
Kuanhou MU
;
Xianqi ZHANG
;
Jie FENG
- Publication Type:Journal Article
- Keywords:
melanocyte;
endothelin-1;
stem cell factor;
adhe sion;
migration
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of endothelin-1 ( ET-1) and stem cell factor (SCF) on melanocyte adhesion and migration in vitr o. Methods Human epidermal melanocytes that had been cultured and purified were treated with ET-1 and observed for adhesion to bovine serum f ibronectin-coated culture dishes. SCF and ET-1 treated cells were also examine d for migration into micropore filters coated with the same protein. Results Compared with SCF group, ET-1 treated melanocytes adhered to the dishes and moved into the filters more easily, especially when th e concentration was at 32 nmol?L -1. When the concentration of ET-1 was 128 mol?L -1 or more, melanocyte adhesion and migration were inhibited ( P
