Expression of nm23-H1 and PCNA in human glioma cells
- VernacularTitle:人脑胶质瘤nm23-H1蛋白及PCNA的表达
- Author:
Zhonglin ZHANG
;
Chuwei LIU
;
Xiaodong ZHANG
;
Gang BAO
;
Shuiping HAN
- Publication Type:Journal Article
- Keywords:
gliomas;
nm23-H1;
proliferating cell nuclear ant igen (PCNA);
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ex pr ession of nm23-H1 protein and proliferating cell nuclear antigen (PCNA) in huma n glioma cells. Methods Expression of nm23-H1 and PCNA in 53 br ain gliomas were detected by immunohistochemistry. Results The immunohistochemistry staini ng of nm23-H1 protein in low-grade astrocytomas (grades Ⅰ and Ⅱ) was significantly higher than that in high-grade astrocytomas (grades Ⅲ and Ⅳ). The immunohistochemistry staining of PCNA in high-grade astrocytomas was s ignificantly higher than that in low-grade astrocytomas. Conclusion The lower expression of nm23-H1 protein and the higher expression of PCNA are correlated with the pathological grade of glioma cells. The expression of nm23-H1 may be used as a hopeful marker for predicting the metastastic potential of gliomas.
