The effect of oxymatrine on airway inflammation and cytokine production in a mouse asthmatic model
- VernacularTitle:氧化苦参碱对小鼠哮喘模型气道炎症及细胞因子的影响
- Author:
Wei HOU
;
Haiyan LIU
;
Airong WANG
- Publication Type:Journal Article
- Keywords:
oxymatrine;
asthmatic model;
airway inflammation;
cytokines
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of oxymatrine o n the airway inflammation and the cytokine production in asthmatic mice. Methods Forty BALB/c mice were divided into four groups in cluding a control group (group A), an asthmatic model group (group B), a dexamet hasone treatment group (group C) and a oxymatrine treatment group (group D). Ast hma mouse models in group B, group C and group D were prepared by injecting oval bumin (OVA) into the abdominal cavity and inhalation of aerosol. Group C were in jected dexamethasone, and group D recceived oxymatrine on day 15 to 22 .The numb er of EOS and the concentration of IL-4 and IL-5 and IFN-? in th e mouse bronchoalveolar lavage fluids (BALF) were detected. Results Oxymatrine could significantly reduce the mumber of EOS and the concentration of IL-4 and IL-5, and increase the level of IFN-? in the BALF of asthmatic mice. Significant difference was fo und between group D and group A or B(P0.05). Conclusion Oxymatrine can remarkably reduce the mumber of i nflammation cells in the BALF, and influence the level of cytokines so as to imp rove airway inflammation in the patients with asthma.
