Relationship between the expression of iNOS and tumor angiogenesis and prognosis of gastric carcinoma
- VernacularTitle:诱导性一氧化氮合酶的表达与胃癌肿瘤血管形成及预后的关系
- Author:
Zhengjun SONG
;
Fenrong WANG
;
Hongxia LI
;
Xinming CHANG
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
initric oxide synthase;
vascul ar endothelial growth factor;
microvascular density
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of indu ci ble initric oxide synthase(iNOS) in gastric carcinoma and its relationship with angiogenesis and the prognosis. Methods Immunohistochemical staining method was used to det ect the expression of iNOS, VEGF CD34 in gastric carcinoma. Results The positive expression of iNOS in gastric carcinom a was 58.70% and iNOS was not detected in normal gastric tissue. The rate of the positive expression of iNOS in stage Ⅳ was higher than that in stageⅠ～Ⅲ. Th e positive expression of iNOS in gastric carcinoma with lymph node metastasis wa s higher than those with no metastasis. The MVD was 59.88? 18.02/HP and 55.5 9+ 19.39/HP in gastric carcinoma positive for iNOS and VEGF, repectively, obviou sly higher than those with negative expression of iNOS and VEGF, repectively ( P
