Gene diagnosis and clinical significance of micrometastases in lymph nodes, peri pheral blood and bone marrow in non-small-cell lung cancer patients
- VernacularTitle:非小细胞肺癌患者淋巴结、外周血、骨髓微转移的MUC1基因诊断及临床意义
- Author:
Zhongxi NIU
;
Qinghua ZHOU
;
Guowei CHE
- Publication Type:Journal Article
- Keywords:
non-small-cell lung cancer;
micrometastases;
MUC1 gene;
lymph node;
peripheral blood;
bone marrow
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To explore the clinical significance of gene diagnosis in detecting micrometastases in lymph node,peripheral blood and bone marrow from non-small-cell lung cancer patients and the correlation to e ach other. Methods:The MUC1 mRNA expression was detected in lymph nodes, p eripheral blood and bone marrow from 31 lung cancer putients and 10 benign p?lm onary lesion patients by nested RT-PCR. Results:The sensitivity of the the RT-PCR technique was 10 -6 in this study. The positive rates of MUC1 mRNA were 54.6%, 32.3% and 22.6% in lymph nodes , peripheral blood and bone marrow from lung cancer patients resp ectively , and highly correlation existed among the three groups(P
