Relationship of chemosensitivity on cancer in vitro and the clinical experience
- VernacularTitle:肿瘤体外药敏试验及其与临床用药之间的关系
- Author:
Yunhua LING
;
Yongqian GE
;
Guochun LU
- Publication Type:Journal Article
- Keywords:
MTT;
chemosensitivity;
inhibitory average
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the relationship of chemosen sitivity in vitro and clinical experience.Methods:To analyze the results of chemosensitivity test in v itro using the MTT assay for 210 cases of five kinds of tumor specimens(85 ova rian cancer, 30 cervical cancer, 26 gastric cancer,41 colorectal cancer and 28 breast cancer), calculate the inhibitory average of each paclitaxel drug to diff erent tumor specimens,then compare the drugs haveing higher inhibitory average w ith the drugs frequently applied clinicaly to that tumor.Results:there is obvious individual variation in in vitro c hemosensitivity test, the variation can be from 0 to more than 60%;however the d rugs having higher inhibitory average correlated to clinical experience.The main theraputic drugs used clinically and also sensitive in in vitro assay were as follows:Taxol,DDP for ovarian cancer; DDP,e-ADM,MMC for cervical cancer ; DDP,5-FU,BLM,MMC for gastric cancer; DDP,MMC,BLM,5-FU for colorectal cancer; e-ADM,ADM,NVB for breast cancer.Conclusions:the chemosensitivity test using the MTT assay may b e useful for individual chemotherapy.
