Doppler ultrasound in evaluating effects of angiotensin converting enzyme inhibition or angiotensin II receptor blocker on coronary hemodynamics in hypertensive patients with left ventricular hypertrophy
- VernacularTitle:超声评价血管紧张素转换酶抑制剂及血管紧张素受体拮抗剂对高血压左室肥厚患者冠状动脉血流动力学的影响
- Author:
Rui XU
;
Yun ZHANG
;
Mei ZHANG
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Hypertension;
Coronary circulation;
Ramipril;
Losartan
- From:Chinese Journal of Ultrasonography
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of angiotensin converting enzyme inhibition(ACEI) or angiotensin II receptor blocker(ARB) on coronary hemodynamics in hypertensive patients with left ventricular hypertrophy(LVH) by Doppler ultrasound.Methods Sixty essential hypertensive patients with LVH were enrolled in this study.All patients were randomly divided into 3 groups: ramipril group,losartan group and combination group.Left ventricular mass(LVM) was calculated by three dimensional echocardiography and coronary hemodynamics was evaluated by transesophageal echocardiography with left anterior descending artery.Coronary flow reserve(CFR) was calculated as the ratio of coronary flow velocity,after intravenous injection of dipyridamole,to rest peak velocity.All the indexes of the coronary hemodynamics were corrected by LVM.Results Fifty patients had complete follow up datum.The systolic blood pressure(SBP),diastolic blood pressure(DBP) and LVM were significantly decreased in ramipril,losartan and combination group after 6 months′ treatment (All P
