Expression and clinical significance of CD13 in gastric cancer
10.3760/cma.j.issn.1673-4203.2013.02.009
- VernacularTitle:胃癌组织中CD13的表达及临床意义
- Author:
Qing ZHOU
;
Xiangling MENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Antigens,CD13;
Immunohistochemistry
- From:
International Journal of Surgery
2013;(2):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of the CD13 in gastric cancer and the relationships between it and the patients' prognosis.Methods The expressions of CD13 were detected by immunohistochemical (SP method) in 104 cases of gastric cancer and 16 cases of normal gastric mucosa.Results The expressions of CD13 in 104 cases of gastric carcinoma and 16 cases of normal gastric mucosa show positive rate were 74％ (77/104) and 0％,respectively.The expressions of CD13 in gastric cancer were higher than in normal gastric mucosa and the difference was statistically significant (P ＜ 0.01).The expressions of CD13 in gastric cancer were not relative to patients' age,gender,and lymph node metastasis (P ＞ 0.05),but to be correlative with tumor sizes,clinical stage,degree of differentiation,and patients' 5-year survival rate (P ＜ 0.05).Conclusions The abnormal expression of CD13 in the gastric cancer may be correlative with the occurrence and development of gastric cancer,which can be an important indicator to evaluate the degree of malignance,guide treatment and assess uncertain prognosis of gastric cancer.
