Relationship of plasma homocysteine and gene polymorphism of homocysteine metabolism related enzyme with diabetic peripheral neuropathy
- VernacularTitle:同型半胱氨酸及其相关酶基因多态性与糖尿病周围神经病变的关系
- Author:
Lei SUN
;
Li CHEN
;
Jianmin REN
;
Dequan WANG
;
Xiuying ZHENG
;
Ling XU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Peripheral neuropathies;
Homocysteine;
Methylenetetrahydrofolate reductase;
Polymorphism (Genetics)
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Sixty cases of type 2 diabetes with diabetic peripheral neuropathy (DPN), 46 cases of type 2 diabetes without DPN and 50 healthy persons were recruited. Plasma homocysteine (Hcy), serum folic acid, vitamin B 12 levels and the mutations of Hcy metabolism related enzyme-methyhenetetrahydrofolate reductase (MTHFR) were assayed in individuals in this study. The results showed that high Hcy, low folic acid and vitamin B 12 levels are related with DPN in the patients with type 2 diabetes. The mutation of MTHFR C677T is associated with diabetes, but not with DPN.
