Immunomodulative effect of Dachengqi granule in treatment of multiple organ dysfunction syndrome
- VernacularTitle:大承气汤在多器官功能障碍综合征治疗过程中的免疫调节作用
- Author:
Shuhua CAO
;
Jinda WANG
- Publication Type:Journal Article
- Keywords:
Multiple organ dysfunction syndrome;
Sepsis;
Dachengqi granule
- From:
Chinese Journal of Trauma
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Dachengqi granule on degree of illness, blood levels of inflammatory mediators, incidence rate and mortality of multiple organ dysfunction syndrome (MODS) so as to discuss its therapeutic mechanism on MODS. Methods A total of 51 patients with systemic inflammatory response syndrome in intensive care unit (ICU) were randomly divided into treatment group (n=26) and control group (n=25) for an observation of clinical manifestation and prognosis. The plasma levels of endotoxin, tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10) and human leukocyte antigen DR (HLA-DR) of each patient were measured in order to determine the curative effect of Dachengqi granule. Results The plasma level of endotoxin in treatment group was ameliorated more significantly than that in the control group. Dachengqi granule could down-regulate the levels of proinflammatory mediators including TNF?, IL-1? and IL-6 and antiinflammatory mediators including IL-4 and IL-10 and up-regulate the expression of HLA-DR (P
