Changes and significance of cytokine signaling suppressor mRNA in burn rats with Staphylococcus aureus sepsis
- VernacularTitle:烫伤脓毒症大鼠细胞因子信号转导抑制因子基因表达的改变及其意义
- Author:
Hongyun LI
;
Yongming YAO
;
Fenghua YAO
;
Ning DONG
;
Yan YU
;
Zhiguo SHI
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
Burns;
Aureus, Staphylococcus;
Sepsis;
Cytokine signaling suppressor
- From:
Chinese Journal of Trauma
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression law of cytokine signaling suppressors (SOCSs) mRNA in burn rats with Staphylococcus aureus sepsis and investigate their potential role in the pathogenesis of postburn sepsis. Methods Wistar rats were inflicted with 20% TBSA Ⅲ? scald, followed by Staphylococcus aureus challenge. Then, the expressions of SOCS1, SOCS2 and SOCS3 mRNA and interferon-? (IFN-?) levels in the liver and lungs were determined. Results With Staphylococcus aureus challenge after burn, IFN-? levels in the liver and lungs were significantly elevated and reached peak at the 0.5th and 6th hours, respectively (P
