Evaluating atrial structural remodeling of canine model with chronic atrial fibrillation and protective effect of captopril by acoustic quantification technique
- VernacularTitle:声学定量技术评价慢性心房颤动犬心房结构重构及卡托普利的保护作用
- Author:
Jianping LI
;
Wei ZHANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Atrial fibrillation;
Atrial function;
Captopril
- From:
Chinese Journal of Ultrasonography
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the atrial structural remodeling of the canine model with chronic atrial fibrillation and the influence of captopril on it by acoustic quantification(AQ) technique. Methods Twenty-six healthy mongrel dogs were randomly divided into three groups, each dog in pacing group(n=11) and treating group(n=9) was implanted with permanent pacemaker(pacing at 400 beats/min) to pace the right atrial appendage for 8 weeks. In treating group all dogs were given captopril (50 mg,2 times a day) three days before pacing to 8 weeks after pacing. Echocardiography exam was performed before pacing and 1, 4, 8 weeks later to moniter the changes of the volume and area of biatria. No pacemaker was implanted in control group(n=6), but the exam was performed in the corresponding time with pacing and treating group. Results Monitered by AQ technique: in pacing group biatrial area was significantly enlarged after 1 week pacing, while biatrial volume began to increase 4 weeks later, 8 weeks after pacing both the area and the volume of biatria were enlarged further; in treating group no changes were found in area and volume of biatria after 1 week pacing, while 4 weeks later it tended to enlarge, 8 weeks later both the volume and the area of biatria showed slight increase compared with those before pacing. But the increase was not as much as the increase in pacing group(P
