Advances in Overcoming Multidrug Resistance of Tumors Caused by mdr1 Gene
- VernacularTitle:逆转mdr1基因导致肿瘤多药耐药性的研究进展
- Author:
Bo LI
;
Lnan YAN
- Publication Type:Journal Article
- Keywords:
Multidrug resistance gene Multidrug resistance
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the advances in overcoming multidrug resistance of tumors caused by mdr1 gene. Methods Different ways of overcoming multidrug resistance of tumors caused by mdr1 gene in the literatures were reviewed. Results One of the important reasons causing multidrug resistance was due to the overexpression of mdr1 gene and its product P-glycoprotein. There were two ways to overcome multidrug resistance of tumors through mdr1 genes mRNA and its product P-glycoprotein effectively.Conclusion The clinical test of the unitary way to overcome multidrug resistance of tumors is unsatisfactory, combining different ways to overcome multidrug resistance of tumors will be the hot spot of tumors research in the future.
