A Study on the Relationship of Formaldehyde Exposure and Nitric Oxide Level in the Lung Tissue of Mice
- VernacularTitle:气态甲醛暴露与小鼠肺组织NO合成水平的相关研究
- Author:
Zi YE
;
Yan YAN
;
Zhisong LU
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
Nitric oxide synthase;
Nitric oxide;
Asthma
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the impact of gaseous formaldehyde exposure on the metabolism of nitric oxide (NO) in the lung tissue of mice. Methods The adult male Kunming mice were randomly divided into 4 groups, treated with gaseous formaldehyde (0,0.5,1,3 mg/m3) for consecutive 72 h in the simulated exposure chamber, the nitric oxide synthase (NOS) activities and the NO positive rate in mice's lung were measured with the reagent kits. Results The lower formaldehyde exposure (≤0.5 mg/m3 ) could decrease NOS activity (compared with the control, P
