Effect of anti-CD_(25) monoclonal antibody on the lymphocyte in the peripheral blood of the recipients of kidney transplantation
- VernacularTitle:抗CD_(25)单克隆抗体对肾移植受者末梢血淋巴细胞的影响
- Author:
Ming CAI
;
Bingyi SHI
;
Yeyong QIAN
- Publication Type:Journal Article
- Keywords:
Transplantation;
Kidney;
Monoclonal antibody;
CD 25
- From:
Chinese Journal of Urology
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibition effect of anti-CD 25 monoclonal antibody (Simulect) to the activated T cells in the recipients of kidney transplantation. Methods Forty-six recipients of renal transplantation were randomly divided into therapeutic group with simulect (23 cases) and control group (23 cases).All recipients in both groups received immunosuppressive therapy with neoral,azatheoprine and predonine conventionally.The recipients in simulect group received additionally 20 mg simulect at 2h preoprative and 4d postoperative,respectively.Several phenotypes of lymphocyte in the peripheral blood of all recipients were observed sequentially with flow cystometer. Results Compared with the control group,the number of activated T cells(CD + 25 ) decreased significantly within 24h after the first dose in the patients who received simulect,and the level of the cells that expressed CD 25 was significantly lower than that of control during the whole observation( P
