Chronic allograft nephropathy associated with active cytomegalovirus infection
- VernacularTitle:肾移植受者巨细胞病毒感染与慢性移植物肾病
- Author:
Pingxian WANG
;
Zhenqiang FANG
;
Chibing HUANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Cytomegalovirus;
Nephropathy;
TGF-?1
- From:
Chinese Journal of Urology
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
114 ?mol/L continuously) and loss of creatinine clearance (Ccr) were also compared among the 4 groups.For patients with renal dysfunction,the renal biopsies were used to determine whether they had CAN. Results Seventy-seven patients were followed up for 3 years,and their data were analyzed.There were 15 cases in Group A,32 in Group B,18 in Group C,and 12 in Group D.In Groups A,B and C,the expressions of TGF-? 1 protein in the allografts at 7 months after transplantation were (5.82?1.32)?10 6,(6.34? 1.47 )?10 6 and (6.58?1.44)?10 6,and the expressions of TGF-? 1 mRNA were 0.84?0.17,0.78? 0.15 and 0.82?0.16,respectively.In Group D the expressions of TGF-? 1 protein and mRNA were (10.47? 2.12 )?10 6 and 1.37?0.25,which were significantly greater than those in Groups A,B and C ( P
