Integrin ?2 and ?3 expression and its clinical value in bladder transitional cell carcinoma
- VernacularTitle:整合素?2和?3在膀胱癌中的表达及意义
- Author:
Fanghu SUN
;
Pengfei SHEN
;
Jiangbo HUANG
- Publication Type:Journal Article
- Keywords:
Integrin;
Bladder neoplasms;
Carcinoma;
Invasion;
Metastasis
- From:
Chinese Journal of Urology
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
50%).RT-PCR results were classified as positive and negative according to the presence or absence of corresponding electrophoretic bands. Results Immunohistochemically,integrin ?2 and ?3 subunits were all expressed strongly in 12 cases of normal bladder tissues (100%).In 53 cases of BTCC tissues,?2 was strongly positive in 10 cases (19%),positive in 22(42%),negative in 21(40%);?3 was strongly positive in 16 (30%),positive in 24 (45%),negative in 13(25%).The expressions of ?2 and ?3 were significantly different between normal and BTCC tissues ( P 0.05).RT-PCR results showed that ?3 expression was positive in all normal tissues (100%) and in 36 (68%) out of the 53 cases of BTCC tissues;the difference was significant ( P 0.05),but ?3 mRNA positive expression was significantly related to clinical stages [T is ～T 1:83%(19/23),T 2～T 4:57%(17/30); P
