Expression and significance of cyclinB1 and CDK1 in gastric cancer
- VernacularTitle:CyclinB1、CDK1在胃癌中的表达及其意义
- Author:
Xiaoli MA
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms?CyclinB?Cyclin-dependent kinases
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological significance of the CyclinB1 and CDK1 expression in stomach carcinogenesis.Methods:The expression of CyclinB1 and CDK1 was examined by immunohistochemistry method in normal epithelium(15 cases),low-differentiated adenocarcinoma (15 cases)and moderate-well-differentiated adenocarcinoma (20 cases).Results:Immunoreaction to Cyclin B1 and CDK1 was mainly localized in the cytoplasm of cells.In stomach carcinogenesis,the positive immunostaining rate of CyclinB1 protein in normal epithelium and adenocarcinoma was 13.3%(2/15),94.3%(33/35) respectively (P
