The change of intestinal mucosal barrier in severe acute pancreatitis
- VernacularTitle:急性重症胰腺炎肠粘膜屏障功能改变的临床研究
- Author:
Limin FENG
;
Jianli WANG
;
Hailong CHEN
- Publication Type:Journal Article
- Keywords:
Pancreatitis,acute necrotizing?Intestinal mucosa?Endotoxins?Tumor necrosis factor?Amine oxidase(copper-containing)?Nitric oxide
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of the changes of the intestinal mucosal barrier in Severe acute pancreatitis.Methods:Twenty patients with Severe acute pancreatitis were admitted and 10 volunteers as the control group.The levels of serum tumor necrosis factor alpha(TNF_?)、nitric oxide(NO)、diamine oxidase(DAO) and the concentration of plasma endotoxin(ET) were measured.The ratio of lactulose to mannitol in urine was detected by HPLC with Pulsed Electrochemical Detection.Results:Compared with the control group,significantly increasing parameters could be seen in all the patients with Severe acute pancreatitis,including the ratio of lactulose to mannitol in urine (P
