Selective prostaglandins EP_1 receptor antagonist inhibits afferent activity of Cunit of saphenous nerve in diabetic rats
- VernacularTitle:选择性前列腺素EP_1受体阻断剂抑制糖尿病大鼠隐神经中C单位的传入活动
- Author:
Qiaojun ZHANG
;
Shuqi YU
;
Yong WANG
;
Li XIANG
- Publication Type:Journal Article
- Keywords:
hyperalgesia;
prostaglandin;
unitary discharge;
diabetes;
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect o f selective prostaglandins EP 1 receptor antagonist SC19220 on the afferent activity of C unit in the saphenous nerve of diabetic rats. Methods The response of C units to sustained 1 min threshol d and suprathreshold stimuli was measured following intradermal injection of EP 1 receptor antagonist SC19220 into the receptive field of C unit of the sa phenous nerve in control and diabetic rats. Results The mechanical threshold of C units in diabetic rat s was obviously decreased compared with that of control rats (P
