The experimental study of protective effects of leg negative pressure treatment on free radical injury from chronic ischemia of lower legs in canines
- VernacularTitle:负压治疗对犬缺血肢体自由基损伤保护的实验研究
- Author:
Guanyu QI
;
Zhong MA
;
Mofan NING
;
Lijun YAN
- Publication Type:Journal Article
- Keywords:
negative pressure (NP);
lipid peroxide (LPO);
su peroxide dismutase (SOD)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effects of le g negative pressure (NP) treatment on free radical injury from chronic ischemia of lower legs in canines. Methods By cutting off the branches of the femoral artery a nd inserting two pieces of spiral wires into the artery of canine posterior limb , we succeeded in duplicating the animal model of arterial occlusive disease in the lower extremity within two weeks. After treatment with LNP for 8 to 10 days, the blood samples of the ischemic legs were collected and the lipid peroxide (L PO) content as well as superoxide dismutase (SOD) activity were measured and ana lyzed, respectively. Results When the ischemic model was set up, PLO content inc reased while SOD activity decreased apparently, compared with those of normal [(35.594?10.753)vs. (24.800?9.011)?mol?L -1, P
