Study on histopathology of the mouse forestomach neoplasm inducd by B(a)P
- VernacularTitle:B(a)P诱导小鼠前胃癌过程中组织病理学变化
- Author:
Xiaofeng ZHANG
;
Baixiang LI
- Publication Type:Journal Article
- Keywords:
benzo(a)pyrene;
forestomach neoplasia;
atypical hyperplasia;
mouse
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To explore the development change of histopathology of the mouse forestomach neoplasm inducd by B(a)P.Methods:A part of the mice were killed each four weeks after they were given benzo(a)pyrene (concentration 5mg/ml) by lavage for four weeks, twice per week. The histopathology of the forestomach was then observed.Results:Forestomach neoplasm was noticed from the 17~(th) week in the mice. Local gland hyperplasia, arrangement disorder gradually developing into glandular abnormality hyperplasia and then transformed into early stomach cancer and finally into aggressive stomach cancer could be observed.Conclusions:Latent period of the mouse forestomach neoplasm induced by B(a)P is about three months. The development course is atrophic gastritis, atypical hyperplasia and stomach cancer.[
