Relationship of chronic myelocytic leukemia and angiogenesis factors
- VernacularTitle:慢性髓细胞性白血病与血管生成因子关系
- Author:
Feng LI
;
Pu CHEN
;
Shanhua ZOU
- Publication Type:Journal Article
- Keywords:
chronic myelocytic leukemia;
angiogenesis;
microvessel density;
vascular endothelial growth factor
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the secretion and gene expression of Angiogenesis factors in the patients with CML and study the effect of Angiogenesis in the occurrence and development of CML. Methods:Concentration of VEGF in peripheral blood was determined by using ELISA. Myeloid tissue was extracted from all CML cases and ITP patients to detect MVD by using CD34 labelling. At the same time the level of VEGF,b-FGF were detected by using RT-PCR in both peripheral blood and myeloid cells.Results:Our results showed that the concentration of VEGF was obviously higher in the peripheral blood of CML patients(177.53?153.45 pg/ml) than in those of control group(73.12?19.82 pg/ml). The gene expression of VEGF and b-FGF were both higher than those of control group. The difference has statistical significance(P
