Analyses of clinical results of treatment with gemcitabine and cisplatin for advanced hormone independent prostate cancer
- VernacularTitle:吉西他滨联合顺铂治疗激素非依赖晚期前列腺癌的临床疗效
- Author:
Zike QIN
;
Guangwei YANG
;
Fangjian ZHOU
- Publication Type:Journal Article
- Keywords:
Gemcitabine;
Cisplatin;
Prostate cancer;
Chemotherapy
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:The aim of this study was to evaluate the clinical efficacy and toxicity of treatment with gemcitabine and cisplatin for hormone independent prostate cancer.Methods:18 cases of advanced hormone independent prostate cancers who received castration and antiandrogen medicines were confirmed to have multiple bone metastatic carcinomas by emission computed tomography(ECT), and hepatic , adrenal and intracranial metastasis were found respectively each in 1 patient, and the value of PSA(prostatic special antigen) had on ascending trend in all patients. Gemcitabine 1000 mg/m~(2) +NS 100 ml was administered by intravenous drip on days 1,8 and cisplatin 100 mg/m~(2) +NS 500 ml was administered by intravenous drip on day 1 or cisplatin 30 mg/m~(2) +NS 250 ml was administered by intravenous drip on days 1 to 5 in each 28-day cycle.Results:Levels of PSA descent to normal titer(
