Expression of ubiquitin in neurofibrillary tangles and senile plaque neurites in hippocampal formation of Alzheimer's disease brain
- VernacularTitle:泛素在阿尔茨海默病神经原纤维缠结和老年斑中的表达
- Author:
Xiangqi TANG
;
Zhengqing LIU
;
Liming TAN
;
Qiuyun TU
- Publication Type:Journal Article
- Keywords:
Ubiquitin;
Neurofibrillary tangles;
Senile plaques;
Hippocampus;
Alzheimer disease
- From:
Chinese Journal of Neurology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To detect the expression and distribution of ubiquitin in neurofibrillary tangles(NFT) and senile plaque neurites in the hippocampal formation of Alzheimer's disease brain and explore the significance of ubiquitin in pathological mechanism of Alzheimer's disease.Methods The expression of ubiquitin in the hippocampal formation of 7 patients with Alzheimer's disease and 5 non-dementia elderly was detected using immunohistochemical technique.Results Neurofibrillary tangles and senile plaque neuritis were labeled by the antibody of ubiquitin in hippocampal formation of Alzheimer's disease brain, but pretangle neurons were not stained. Containing NFT neurons stained by ubiqutin antibody immunoreactive products were distributed more in the CA1 and CA2 (42.13?0.65, 30.57?0.78 respectively)than those in CA3 and CA4 (12.43?0.24?18.34?0.81 respectively)of the hippocampal formation (P
