First-phase insulin secretion and its components in the first-degree relatives of type 2 diabetics
- VernacularTitle:2型糖尿病患者一级亲属第一时相胰岛素分泌及其组分的变化
- Author:
Xinrong LI
;
Benzhang ZHU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
First-degree relatives;
First-phase of insulin secretion;
Proinsulin;
True insulin;
Immunoreactive insulin
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of first-phase insulin secretion and its components in the first-degree relatives of Chinese type 2 diabetics with normal glucose tolerance and their correlation with type 2 diabetes. Methods The first-degree relatives of type 2 diabetes (Group B, n=35), newly diagnosed type 2 diabetic patients (Group C, n=35) and health subjects (Group A, n=21) were recruited. Immune reactive insulin (IRI), proinsulin (PI), and true insulin (TI) were determined during intravenous glucose tolerance test (IVGTT) in each subjects. IRI was determined with radioimmunoassay kit, while PI and TI with ELISA kits. Results (1) For the fasting sera, the levels of IRI and PI showed significant differences (both P
