Adrenomedullin against insulin resistance
- VernacularTitle:肾上腺髓质素拮抗胰岛素抵抗
- Author:
Guangqun XING
;
Xiuzhen ZHAO
;
Liqiu LIU
;
Tatsuo SHIMOSAWA
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Oxidative stress;
Adrenomedullin;
Adrenomedullin-knockout mouse
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To reveal the involvement of oxidative stress in hypertension and insulin resistance. Angiotensin Ⅱ was given to adrenomedullin-knockout mice for 4 weeks. 4-Hydroxy-TEMPOL, a superoxide scavenger mimetic was also employed. The results suggested that adrenomedullin may exert a protective effect against insulin resistance via its intrinsic antioxidant effect.
