HIV-1 protease inhibitor nelfinavir decreases insulin secretion from rat insulinoma INS-1 cells
- VernacularTitle:HIV-1蛋白酶抑制剂Nelfinavir降低大鼠胰岛素瘤INS-1细胞胰岛素释放
- Author:
Jiaqiang ZHOU
;
Schutt MORTEN
- Publication Type:Journal Article
- Keywords:
HIV protease inhibitors;
Nelfinavir;
INS-1 cells;
Insulin secretion
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Rat INS-1 cells treated with HIV-1 protease inhibitor Nelfinavir for 48 h showed that both basal and glucose-stimulated insulin secretion decreased, the latter was more marked, suggesting that long-term treatment with Nelfinavir may impair ?-cell function.
