The mechanism study of interleukin-1? induced airway hyperresponsiveness in guinea pigs
- VernacularTitle:白介素-1?致豚鼠气道高反应性作用机制的研究
- Author:
Xueqin CHEN
;
Xia CAO
;
Jiong YANG
;
Zuoyan CAO
;
Zhenlian LIU
- Publication Type:Journal Article
- Keywords:
Interleukin-1?;
Neurokinin;
Airway hyperresponsiveness
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mechanism of interleukin-1?(IL-1?) induced AHR.Methods:The authors work out an original model of AHR induced by IL-1? administered intratracheally to guinea pigs,and investigate the effects of neurokinin released from intrinsic airway neurons on the development of this airway hyperresponsiveness,PC 20 values were significantly lower in animals given IL-1? than that in controls( P 0 05),showing complete inhibition of IL-1? induced AHR by capsaicin pretreatment.PC 20 values were significantly higher in animals with NK 1 receptor antagonist pretreatment than that in animals exposed to IL-1?( P
