Submucosal injection plus single intravesical instillation of epirubicin for primary superficial bladder carcinoma recurrence
- VernacularTitle:表阿霉素黏膜下浸润注射加单次灌注预防浅表性膀胱癌术后复发的研究
- Author:
Jian YAO
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Epirubicin;
Recurrence
- From:
Chinese Journal of Urology
2001;0(10):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To evaluate the efficacy of submucosal injection plus single intravesical instillation of epirubicin for primary superficial bladder cancer recurrence. Methods A total of 36 patients with superficial bladder carcinoma (10 cases of T a and 26 of T 1;11 cases of G 1,20 of G 2 and 5 of G 3) underwent partial cystectomy.Intraoperatively,submucosal multiple injections of epirubicin (total dose of 30 mg) were performed,and intravesical instillation of 120 mg epirubicin was conducted immediately after operation. All the patients were followed up for 1 to 4 years (mean 2.8 years). Results The postoperative disease free survival rates were 100.0%,91.7% (33/36) and 88.9% (32/36) at 1,2 and 3 years, respectively.The total recurrence rate was 11.1% (4/36),and adverse effect rate was 36.1% (13/36). Conclusions Intraoperative submucosal multiple injections combined with single intravesical instillation of epirubicin immediately after operation are effective for prophylaxis of primary superficial bladder cancer recurrence,with advantage of being more cost effective and fewer side effects.
