Activation of p44/42 mitogen-activated protein kinase pathway involves in formation of hypertrophic scar and keloid
- VernacularTitle:丝裂素原激活的蛋白激酶通路与异常瘢痕形成
- Author:
Hongsen BI
;
Dongming CHEN
;
Jianning LI
- Publication Type:Journal Article
- Keywords:
Cicatrix;
Mitogen-activated protein kinases;
Fibro blasts
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of p44/42 mitogen -activated protein kinase (p44/42MAPK) and Phospho-p44/42MAPK in cicatrix (hy pertropic scars and keloids) and to aim at exploring the role of activated p44/ 42 MAPK pathway in development of cicatrix. Methods In or der to analyse the differences, 10 samples of normal skin (NS), hypertropic scar s (HS) and keloids (K) were collected, and then the extracted cytoplasmic protei ns from each tissue were examined by Western blotting for p44/42 MAPK and Phosph o p44/42MAPK and immunohistochemical staining with specific antibodies was emplo yed to determine that in fibroblasts of K, HS and NS. Results There was no evident difference of p44/42MAPK in the tissues and fibroblas ts between cicatrix and NS, but Phospho-p44/42MAPK was obviously higher in cica trix than that in NS. In cicatrix, there was no evident difference of p44/42MAPK in tissues between HS and K, while in fibroblasts, Phospho-p44/42MAPK in K was much higher than in HS. Conclusion Activation of p44/42MA PK pathways involves in formation of cicatrix.
