A kinetic study on the relationship between IL-5,sIL-2R and eosinophil apoptosis in asthmatic patient's airway inflammation
- VernacularTitle:哮喘患者痰嗜酸性粒细胞凋亡与IL-5及sIL-2R相关性的研究
- Author:
Junyang XU
;
Fengxia JIANG
;
Yunji QIU
- Publication Type:Journal Article
- Keywords:
Asthma;
Cytokines;
Eosinophil;
Apoptopsis;
relativity
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between eosinophil(EOS) and IL-5,sIL-2R in asthmatic patients in sputum. Methods:Thirty asthmatic patients (asthmatic group) during exacerbation and stable stage and twenty healthy persons were selected.IL-5 and sIL-2R in sputum were determined by ELISA ,EOS apoptosis was identified by flow cytometre.Results:IL-5 ,sIL-2R and EOS apoptosis percentages in the patients during exacerbation and stable stage in sputum were increased significantly,.There were no expression of EOS apoptosis in the healthy persons. Data analyses revealed a negative correlation between EOS apoptosis and the levels of IL-5, and a closer correlation between the percentages and IL-5.Conclusion:EOS underwent apoptosis in asthmatic airway and EOS apoptosis was regulated by IL-5.There were no correlation between EOS apoptosis and sIL-2R.
