The changes of brain-gut peptides and immunologic function in the rats before and after relief of biliary obstruction
- VernacularTitle:胆总管梗阻解除前后脑肠肽及免疫水平变化的实验研究
- Author:
Xuting ZHI
;
Xiangqin HOU
;
Tao LI
;
Kai SUN
;
Fengjun LIU
- Publication Type:Journal Article
- Keywords:
Cholestasis?Vasoactive intestinal peptide?Substance P?Interleukin-2?Immunity,cellular
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes and the adjusting effects of brain-gut peptides (BGP) on immunologic function in the rats before and after relief of biliary obstruction.Methods:One hundred Wistar rats were randomly divided into five groups,including sham common bile duct ligation group (group A),common bile duct ligation group (group B),sham relief of biliary obstruction + normal saline group (group C) ,relief of biliary obstruction + normal saline group (group D) and relief of biliary obstruction + Sandostatin (group E).At 1d,7d after the operation of each group,the changes of plasma vasoactive intestional peptide (VIP),substance P(SP),serum interleukin-2(IL-2) and serum T-lymphocytic subsets (CD4 +,CD8 +)were determinded by radioimmunoassay and flowcytometry .Results:Plasma VIP and SP were increased in group B compared with group A(P
