The relationship between the reexpression of nestin protein and the expression of bFGF protein in cerebral ischemia
- VernacularTitle:脑缺血组织nestin蛋白重新表达及其与碱性成纤维细胞生长因子表达的关系
- Author:
Xi XU
;
Xinli XIAO
;
Jianyun ZHENG
;
Yong LIU
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
nestin;
basic fibroblast growth factor (bFGF);
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the reexpression of nestin protein and the expression of basic fibroblast growth factor (bFGF) protein in cerebral ischemia. Methods By using rat permanent cerebral ischemia as a model, immunohistochemical staining was used to observe the expression of nestin protein and the bFGF protein 1,3,7,14 and 28 days after cerebral ischemia. Results The number of nestin cells around the ischemic area increased 1 to 3 days after cerebral ischemia,but it decreased 7 days after cerebral ischemia. However, the number of bFGF cells around the ischemic area increased obviously 14 days after cerebral ischemia, but it decreased 28 days after cerebral ischemia. Conclusion Reexpression of nestin protein around ischemic cerebral tissues does not need the nourishment and susteinance of bFGF protein; nestin cells around ischemic foci are originated from astrocytes which replay the course of fetation.