Synergistic effect of all-trans-retinoic acid and interferon-? on proliferation, apoptosis and invasion of human glioma cell line SHG-44
- VernacularTitle:全反式维甲酸和干扰素-?协同作用对人胶质瘤细胞系SHG-44增殖、凋亡及侵袭力的影响
- Author:
Huaici DENG
;
Xiaozhi ZHANG
;
Long ZHANG
- Publication Type:Journal Article
- Keywords:
all-trans-retinoic acid;
interferon-?;
glioma
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the synergistic effect of all-trans-retinoic acid (ATRT) and interferon-?(IFN-?) on the proliferation, apoptosis and invasion of human glioma cell line SHG-44. Methods The glioma cellular proliferation capacity was observed with MTT assay, the cell cycle distribution and the apoptotic rate were measured with flow cytometry, and the invasion capacity was assayed in a Transwell cell culture chamber. Results The proliferation capacity and invasion capacity decreased, and the apoptotic rate and percentage of cells in G 1 phase increased in the glioma cells treated by combination of RATA and IFN-?. Conclusion RATA and IFN-? combined have synergistic effects in inhibiting glioma cells and inducing the apoptosis.
