Feasibility of ~1H-MRS in the DEN induced rat hepatocellular carcinoma by a new 1.5T MR scanner
- VernacularTitle:新型1.5T MR对大鼠诱发肝癌进行~1H-MRS扫描可行性的初步分析
- Author:
Weidong ZHAO
;
Sheng GUAN
;
Weijun PENG
- Publication Type:Journal Article
- Keywords:
rat hepatocellular carcinoma;
1H-magnetic resonance spectroscopy;
magnetic resonance imaging
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the feasibility of 1 H-magnetic resonance spectroscopy ( 1 H-MRS) in the chemical induced rat hepatocellular carcinoma(HCC) model by a new 1.5T MR set and endeavor to have an initial understanding of the characteristics of its cancer development. Methods:Diethylnitrosamine (DEN) induced rat HCC models(n=30) were established. At different intervals rats were randomly scanned before being killed on the following day. Their livers were dissected for histopathologic study. Results:Three rats died unexpectedly. 27 rats (90%) developed liver lesions and were investigated according to the plan. T 1 WI is good for demonstration of anatomic structure and T 2 WI at showing the lesions in detail. The scanning methods have been improved gradually. 1 H-MRS results were satisfactory for 64% of the single-voxel and 50% of the multi-voxel respectively. Conclusions:DEN induced rat HCC model is suitable for the Medical Imaging studies and liver 1 H-MRS scan is practical with this new 1.5T unit.
