Regulative effect of arsenic trioxide on the drug-resistant protein in MR_2 cell lines
- VernacularTitle:氧化砷对MR_2细胞耐药蛋白的调节作用
- Author:
Xiaoping QIAN
;
Baorui LIU
;
Lifeng WANG
- Publication Type:Journal Article
- Keywords:
MR2 cell line;
arsenic trioxide;
P-glycoprotein;
mutidrug resistance protein
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To detect the action of arsenic trioxide(As 2O 3) on the expression of tumor drug-resistant protein. Methods:APL cell line MR 2 resistant to all-trans retinoic acid(ATRA) was used for in vitro studies. APL cell line NB 4 was used for control. The expressions of P-glycoprotein(Pgp), multidrug resistance protein(MRP)were determined by immunocytochemical assays. Results:The expression of Pgp was significantly higher in MR 2 cell line(30%-40%) than in NB 4 cell line(10%-20%)(P
