Ultrasonographic observations on proliferative activity and invasiveness of rabbit renal VX_2 tumor
- VernacularTitle:兔肾VX_2肿瘤模型超声显像与肿瘤增殖活性及侵袭性的关系
- Author:
Wen WANG
;
Yunyou DUAN
;
Tiesheng CAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Kidney neoplasms;
Rabbits;
Disease models,animal
- From:
Chinese Journal of Ultrasonography
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the ultrasonographic parameters describing the tumor and proliferative activity, invasiveness of the rabbit renal VX 2 tumor. Methods Animal models were established in 56 rabbits,in which left kidneys were transplanted with VX 2 tumor. The second harmonic imaging and video-density quantitative determination were applied to observe the size, echo-intensity and edge echo-pattern of the rabbit renal VX 2 tumor. The findings were compared with those of histopathologic section and DNA analysis calculated with the flow cytometer. Results The number of tumor cell with higher proliferative index(PI) and ploidy cell rate(PCR) increased with the tumor size. The tumors of hyperecho and more blood flow with obvious necrosis tissue, fibrotic lesion and blood sinusoid got higher PI and PCR than the tumors of hypoecho and less blood flow, while there was no statistic significant correlation between the echoic patterns of the tumor edge and DNA analysis.Conclusions The ultrasonographic parameters describing the tumor, such as the size, echo-intensity and blood flow, can be used to evaluate the proliferative activity and invasiveness of the renal tumor.
