Expressions of proliferating cell nuclear antigen, bcl-2 and c-myc proteins, and DNA ploidy in thyroid tumor cells
- VernacularTitle:甲状腺肿瘤细胞增殖细胞核抗原、bcl-2及c-myc的表达和DNA倍体
- Author:
Dexiang LI
;
Botao LUO
;
Hong ZHENG
;
Yangqiang ZHOU
;
Kelun CHENG
;
Congmei LUI
;
Lizhi SHANG
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Gene;
Proliferating cell nuclear antigen;
bcl-2;
c-myc;
Ploidies
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of proliferating cell nuclear antigen (PCNA), bcl-2, and c-myc protein, and to explore diagnostic value of DNA ploidy in benign and malignant thyroid neoplasms. Methods The expressions of PCNA, bcl-2 and c-myc proteins in 36 cases of thyroid adenomas and 37 cases of thyroid carcinomas were examined by immunohistochemistry technique. DNA ploidy was measured by imaging analysis technique in 8 cases of thyroid adenomas and 17 cases of thyroid carcinomas. Results Among thyroid carcinomas, the positive rates of PCNA (43.02?31.16)% and c-myc protein 89.2% were significantly higher than those of thyroid adenomas (16.15?9.28)% and 50.0% respectively (both P
