Effect of Fas ligand expression of testicular Sertoli cells on cotransplanted parathyroid cells
- VernacularTitle:Fas配体表达对甲状旁腺细胞移植的影响
- Author:
Xiuqing DUAN
;
Chun SONG
;
Ping XU
;
Chunfang SONG
- Publication Type:Journal Article
- Keywords:
Fas ligand;
Parathyroid;
Cell transplantation;
Sertoli cells;
Rats, Wistar;
Rats, Sprague-Dawley
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Fas ligant (FasL) expression of testicular Sertoli cells on cotransplanted parathyroid cells. Methods Various numbers of rat testicular Sertoli cells with FasL expression and allogeneic parathyroid cells were cotransplanted. Allograft survival, change in cell components, apoptosis of infiltrative lymphocytes and parathyroid function were analyzed. Results The parathyroid cells when transplanted alone were all rejected, the mean survival time of allografts was (17?4)days. When parathyroid cells were cotransplanted with testicular Sertoli cells, the survival time of allografts was prolonged over 60 days. When the quantity of testicular cells was increased to 4?10~6, 6 of 8 rats maintained normal serum calcium and PTH levels throughout the follow-up period of 60 days (P
