Effect of mild and moderate iodine excess on thyroid function and morphology in iodine deficiency rats
- VernacularTitle:轻、中度碘过量对碘缺乏大鼠甲状腺功能和形态的影响
- Author:
Tianshu GAO
;
Weiping TENG
- Publication Type:Journal Article
- Keywords:
Iodine excess;
Iodine deficiency;
Thyroid, Function and morphology;
Rat, Wistar
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of mild and moderate iodine excess on thyroid function and morphology in Wistar rats with iodine deficiency. Methods Rats with iodine-deficiency were prepared by drinking 1% postassium perchlorate solution followed by drinking double distilled water (DDW) containing 0 ?g/L (iodine deficient control) iodine load, 840 ?g/L or 1680 ?g/L iodine load. Normal rats in DDW group drank DDW with 0 ?g/L iodine and had common diet. Serum TSH was measured with solid phase radioimmunoassay (IRMA) and serum TT_4, TT_3, rT_3 and thyroid TT_4 with radioimmunoassay (RIA). Thyroid morphological changes were observed under optical and electron microscopes. Metamorphic imaging system was used to measure the height of thyrocytes and the area of thyroid follicular cavities. Results At the 90 th day after starting treatment, serum TSH levels in 840 ?g/L iodine group and 1680 ?g/L iodine group were markedly lower than that in iodine-deficient control group (both P
