Acute action of glucocorticoid on catecholamine secretion of adrenal chromaffin cells in rats
- VernacularTitle:糖皮质激素对大鼠肾上腺嗜铬细胞分泌儿茶酚胺的急性效应
- Author:
Jihong LIU
;
Zhi CHEN
;
Chunping YIN
- Publication Type:Journal Article
- Keywords:
Adrenal medulla;
Chromaffin cells;
Catecholamine;
Dexamethasone;
Nicotine receptor channel current;
Calcium channel current
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
By using the whole-cell clamp-patch technique, the effects of dexamethasone on calcium channel current (Ica) and nicotine receptor channel current (I_(NIC)) were examined. The acute action of glucocorticoid on adrenal medullary chromaffin cell (AMCC) of rats was a significant inhibition of I_(NIC), while no apparent effect was observed on Ica induced by electricity. The results suggest that the acute action of glucocorticoid on catecholamine release in rat AMCC may be directly related to nicotine receptor.
