The effect of astragalus polysacchrides on the antiphospholipid antibodies in SLE mice
- VernacularTitle:黄芪多糖对红斑狼疮小鼠6种抗磷脂抗体的影响
- Author:
Xiaoqin WANG
;
Yuming ZHAO
;
Yakun WANG
;
Hongduo CHEN
- Publication Type:Journal Article
- Keywords:
Astragalus polysacchrides;
Antiphospholipid antibody;
SLE mice
- From:
Chinese Journal of Immunology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of astragalus polysacchrides on anticardiolipin, antiphosphatidyl choline, antiphosphatidyl serine, antiphospha-tidyl inositol, antiphosphatidic acid and antiphosphatidyl ethanolamine antibodies (aCL, aPC, aPS, aPI, aPA, aPE) in SLE mice. Methods:19 NZB?NZW F1 female mice were divided randomly into 3 groups: group PG2I (25 mg/kg/d), group PG2II (50 mg/kg/d), group NS (0.2 ml/d). Select BXSB and C57BL/6 female mice as control. The level of antiphospholipid antibodies in these mice were examined by ELISA. Results:Compared with group NS, the A value in group PG2II were decreased significantly, however, A value in group PG2I were elevated slightly. There were no difference among group PG2II, BXSB and C57BL/6. The level of antiphospholipid antibodies in group NS and PG2I were increased significantly compared with that of BXSB and C57BL/6 mice. Conclusion:The generation of antiphospholipid antibodies can be improved by low dose of PG2 and inhibited by high dose of PG2.
