A study of 5, 10 - Methylenetetrahydrofolate Reductase ( MTHFR ) polymorphism among the Korean population.
- Author:
Moon Soo KANG
1
;
Dong Ho YANG
;
Jong Soon CHOI
;
Kwon Soo HA
;
Sae Yong HONG
Author Information
1. Department of Internal Medicine, Soonchunhyang University Chunan Hospital Choongchungnam-Do, Korea.
- Publication Type:Original Article
- Keywords:
Hyperhomocysteinemia;
MTHFR;
Hypertension
- MeSH:
Africa;
Atherosclerosis;
Chungcheongnam-do;
Genotype;
Health Services;
Homocysteine;
Humans;
Hyperhomocysteinemia;
Hypertension;
Metabolism;
Methylenetetrahydrofolate Reductase (NADPH2)*;
Plasma;
Prevalence;
Risk Factors;
Vascular Diseases
- From:Korean Journal of Medicine
1999;56(1):41-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperhomocysteinemia has been recognized as an independent risk factor which causes atherosclerosis. The genetic mutation in MTHFR, an enzyme required for efficient homocysteine metabolism, produces a thermolabile enzyme with reduced activity. It has been suggested that thermolabile MTHFR is associated with vascular disease due to increased plasma homocysteine concentration. This study is a preliminary research for identifying the relationship between the MTHFR gene mutation and hypertensive subjects by examining the prevalence of 677 C--
