Significance of the changes of platelet activation in the elderly patients with obstructive sleep apnea -hypopnea syndrome
- VernacularTitle:血小板活化对老年阻塞性睡眠呼吸暂停低通气综合征患者的影响
- Author:
Huiping FENG
;
Huiqing FENG
;
Yuzhen SHI
;
Ning SONG
- Publication Type:Journal Article
- Keywords:
Sleep apnea obstructive;
P-selectin;
Platelet glyco-protein GPⅡb-Ⅲa complex
- From:
Chinese Journal of Geriatrics
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate changes of platelet activation in the elderly patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)before and after the application of nasal continuous positive airway pressure(nCPAP). Methods Ninety patients diagnosed as OSAHS by polysomnography(PSG)were selected as trial group,30 non-OSAHS by PSG were as control group, and 16 severe OSAHS patients were treated by nCPAP and taken as nCPAP therapy group. GMP-140 and GPⅡb/Ⅲa were measured by ELISA and compared in these groups. Results Plasma levels of GMP-140 and GPⅡb/Ⅲa of patients with moderate and severe OSAHS were (16.6?2.3)?g/L vs (18.9?3.1)?g/L, and 38 468?952/ 49 673?1037 vs 39 867?1264/50 899?2476 respectively; and those of control group were (14.8?2.1) ?g/L, 37 672?769/ 48 469?1672 respectively.Plasma levels of GMP-140 and GPⅡb/Ⅲa were significantly higher in patients with moderate to severe OSAHS than those in control group(P
