Effect of homocysteine on the expression of protooncogene and neointimal hyperplasia in rat carotid arteries after balloon injury
- VernacularTitle:同型半胱氨酸对球囊损伤大鼠颈动脉原癌基因表达及新生内膜增生的影响
- Author:
Huipu XU
;
Yibai FENG
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Carotid artery injuries;
Endothelium, vascular;
Proto-oncogene
- From:
Chinese Journal of Geriatrics
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of homocysteine(Hcy) on the expression of c-fos and c-jun mRNA and neointimal hyperplasia in rat common carotid artery, and to explore the possible mechanism of homocysteine exacerbating neointima formation after balloon injury. Methods The mRNA expression of c-fos and c-jun were detected by semi-quantitative RT-PCR in the common carotid artery. The morphology of arterial intima and media was studied by optical microscopy and image analysing system. Results The mRNA expression of c-fos and c-jun was significantly elevated in the low methionine(LM)〔(1.40?0.21),(1.43?0.25)〕 and high methionine(HM) 〔(1.68?0.27),(1.71?0.30)〕 than that in the control group 〔(1.10?0.15),(1.00?0.13), P
