Granule tissue remodeling under neoepithelium in pig's full thickness dermal wounds
- VernacularTitle:猪全层皮肤缺损创面新生上皮下肉芽组织的改建
- Author:
Jinqing LI
;
Xiaobing FU
;
Shaozong CHEN
;
Xueyong LI
;
Biao CHENG
- Publication Type:Journal Article
- Keywords:
Wound healing;
Granule tissues;
Tissue remodeling
- From:
Chinese Journal of Trauma
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the granule tissue remodeling under neoepithelium in minitype pigs' full thickness dermal wounds and discuss the relation between the remodeling and possible ulcers or scars. Methods After the establishment of eight full-thickness dermal wound models with the diameter of 4 cm on the back of six minitype pigs, the specimens were collected from wound edge and wound center immediately, 3, 6, 9, 12, 15, 20, 25, 30 and 45 days, respectively after injury for HE staining, immunohistochemical staining and Van Gieson staining and then observed under light microscope to count the cell number, fibroblasts and vascular endothelial cells as well as evaluate the quantity and arrangement of collagens. Results The mean wound healing time was (29.3?1.8) days. After 9-25 days, the granule tissues in the wound center contained more cells, fibroblasts, collagen and vascular endothelial cells than those under neoepithelium of wound edge (P 0.01). Meanwhile, the collagen quantity and arrangement style of granule tissues under neoepithelium during wounds healing (12-30 days) assembled those under neoepithelium 15 days after wound healing. Conclusion Granule tissue remodeling exists during the healing of full thickness dermal wound.
